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Formulation and Characterization of Thermoplastic Polyurethane-Based Steroid Eluting Devices

[+] Author Affiliations
Jessica Doan, Peter Phommahaxay, Sarah Olson, Matthew A. Petersen

ProMed Pharma LLC, Minneapolis, MN

Paper No. DMD2019-3254, pp. V001T10A010; 3 pages
doi:10.1115/DMD2019-3254
From:
  • 2019 Design of Medical Devices Conference
  • 2019 Design of Medical Devices Conference
  • Minneapolis, Minnesota, USA, April 15–18, 2019
  • ISBN: 978-0-7918-4103-7
  • Copyright © 2019 by ASME

abstract

We describe the formulation and manufacture of thermoplastic polyurethane (TPU)-based steroid-eluting components and the development of a versatile, material-agnostic analytical method for their rapid characterization. The impact of materials, formulation, and processing on controlled release behavior was characterized and compared to current industry standard components under physiologically relevant conditions. The combination of factors modulated drug release, offering new avenues for controlling the release of steroids from implantable medical devices.

Copyright © 2019 by ASME

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