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Novel Bio-Synthetic Graft for Tracheal Reconstruction in Pediatric Patients With Congenital Tracheal Stenosis: In Vitro Studies of Axial, and Bending Biomechanics

[+] Author Affiliations
Teja Karkhanis, Brian Juarez, Balakrishna Haridas

Texas A&M University, College Station, TX

Farhan Zafar, David Luis-Simon Morales

University of Cincinnati, Cincinnati, OH

Paper No. DMD2019-3226, pp. V001T10A006; 5 pages
  • 2019 Design of Medical Devices Conference
  • 2019 Design of Medical Devices Conference
  • Minneapolis, Minnesota, USA, April 15–18, 2019
  • ISBN: 978-0-7918-4103-7
  • Copyright © 2019 by ASME


Congenital Tracheal Stenosis (CTS) is a rare birth defect requiring surgical interventions when it affects more than 30% of the trachea. Slide tracheoplasty, the current standard of care, is associated with reinterventions including the need for intraluminal stenting leading to increased airway infections. We propose a novel Bio-Synthetic Graft for long segment tracheal reconstructions in CTS patients. Preliminary bench performance testing, using lamb tracheas, shows that the Bio-Synthetic Graft reconstructed tracheas have comparable radial, axial and bending stiffness in hyperextension to healthy tracheas and resist collapse when subjected to bending in flexion. These results suggest that Bio-Synthetic Graft could be a promising alternative to existing solutions for long segment CTS.

Copyright © 2019 by ASME



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