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Giant Magnetoresistive Based Handheld System for Rapid Detection of Human NT-proBNP

[+] Author Affiliations
Wei Wang, James Collins

University of Minnesota, Saint Paul, MN

Todd Klein

Zepto Life Technology, Saint Paul, MN

Paper No. DMD2019-3264, pp. V001T04A003; 2 pages
  • 2019 Design of Medical Devices Conference
  • 2019 Design of Medical Devices Conference
  • Minneapolis, Minnesota, USA, April 15–18, 2019
  • ISBN: 978-0-7918-4103-7
  • Copyright © 2019 by ASME


In this work, we developed giant magnetoresistive (GMR) based handheld biosensing systems that serve as platform for detecting human NT-proBNP. This assay takes advantages of high sensitivity and real-time signal readout of GMR biosensor. The limit of detection was estimated to be less than 0.01ng/mL, and detection range covered from 0.01 ng/mL to 5 ng/mL was obtained. The assay can be completed within 20 min, which is very important for further development of point-of-care testing. The proposed GMR handheld system is also successfully used for the detection of real NT-proBNP human samples. It can be foreseen that this handheld detection system could become a robust contender in the applications of in vitro biomarker diagnostics.

Copyright © 2019 by ASME
Topics: Testing , Biosensors , Signals



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