Full Content is available to subscribers

Subscribe/Learn More  >

Design of a Skin Grafting Methodology for Burn Wound Using an Additive Biomanufacturing System Guided by Hyperspectral Imaging

[+] Author Affiliations
Houzhu Ding, Antonio Dole, Filippos Tourlomousis, Robert C. Chang

Stevens Institute of Technology, Hoboken, NJ

Paper No. MSEC2016-8588, pp. V002T03A003; 11 pages
  • ASME 2016 11th International Manufacturing Science and Engineering Conference
  • Volume 2: Materials; Biomanufacturing; Properties, Applications and Systems; Sustainable Manufacturing
  • Blacksburg, Virginia, USA, June 27–July 1, 2016
  • Conference Sponsors: Manufacturing Engineering Division
  • ISBN: 978-0-7918-4990-3
  • Copyright © 2016 by ASME


Skin thermal burn wounds are classified by depth and require different levels of medical intervention. In this paper, the authors propose a novel treatment method where hyperspectral imaging (HSI) is applied to measure skin burn wound information that guide an additive biomanufacturing process to print a custom engineered skin graft in three dimensions (3D). Two dimensional principle component analysis (2DPCA) for noise reduction is applied to images captured by HSI in the visible wavelength range from 375 nm to 750 nm. A multivariate regression analysis is used to calculate hemodynamic biomarkers of skin burns, specifically the total hemoglobin concentration (tHb) and oxygen saturation (StO2) of the injured tissue. The biomarker results of the skin burn images are mapped spatially to show the burn wound depth distribution. Based on the biomarker values, the burn area is segmented into different sub areas with different burn degrees. Depth profiles of deep burns which require skin grafting are extracted from the burn distribution map. Next, each profile is processed to generate an additive biomanufacturing toolpath with a prescribed internal tissue scaffold structure. Using the toolpath, a 3D printer processes a custom graft from an alginate polymer hydrogel material. Alginate is chosen as the print material since it can be stretched into aligned fibers to create a porous structure that facilitates oxygen and nutrient uptake. The resultant printed construct demonstrates the feasibility of fabricating patient-specific tissues with custom-geometry grafts for treating clinical burns.

Copyright © 2016 by ASME



Interactive Graphics


Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging and repositioning the boxes below.

Related eBook Content
Topic Collections

Sorry! You do not have access to this content. For assistance or to subscribe, please contact us:

  • TELEPHONE: 1-800-843-2763 (Toll-free in the USA)
  • EMAIL: asmedigitalcollection@asme.org
Sign In