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Bioreactor Development for Cultivating Tenocytes on Collagen Foils Supported by Constitutive Modelling

[+] Author Affiliations
Wolfgang Willenberg, Marcus Stoffel, Dieter Weichert

RWTH Aachen University, Aachen, Germany

Paper No. IMECE2013-64498, pp. V009T10A053; 8 pages
  • ASME 2013 International Mechanical Engineering Congress and Exposition
  • Volume 9: Mechanics of Solids, Structures and Fluids
  • San Diego, California, USA, November 15–21, 2013
  • Conference Sponsors: ASME
  • ISBN: 978-0-7918-5638-3
  • Copyright © 2013 by ASME


For medical applications, it is desirable to cultivate tendon cells. In addition to the many biochemical requirements for successful cultivation, mechanical stimulation also plays an important role. Especially, it is well known that tendon cells de-differentiate quickly if they are not put under physiological conditions. For this reason, a new bioreactor for the investigation and cultivation of tenocytes is developed, in which tenocytes are seeded on a carrier material. To be able to identify the real loads the tenocytes are subjected to, the material properties of the carrier material are found by performing material tests followed by a numerical analysis.

Copyright © 2013 by ASME
Topics: Modeling , Bioreactors



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