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Adhesin-Specific Nanomechnical Cantilever Biosensors for Detection of Microorganisms

[+] Author Affiliations
Tzuen-Rong J. Tzeng, Yunyan R. Cheng, Reza Saeidpourazar, Siddharth Sanjeev Aphale, Nader Jalili

Clemson University, Clemson, SC

Paper No. MNHMT2009-18487, pp. 275-282; 8 pages
doi:10.1115/MNHMT2009-18487
From:
  • ASME 2009 Second International Conference on Micro/Nanoscale Heat and Mass Transfer
  • ASME 2009 Second International Conference on Micro/Nanoscale Heat and Mass Transfer, Volume 1
  • Shanghai, China, December 18–21, 2009
  • Conference Sponsors: Nanotechnology Institute
  • ISBN: 978-0-7918-4389-5 | eISBN: 978-0-7918-3864-8
  • Copyright © 2009 by ASME

abstract

Considerable evidence has indicated that lectins (adhesins) on bacterial surfaces play an important role in the initiation of infection by mediating bacterial adherence to epithelial cell, especially in the gastrointestinal and urinary tracts. Many bacteria express adhesins on their surfaces in the form of specialized organelles that seek and bind to cognate receptors on the surface of mucosal cells. Some of these specific receptors have been reported and many of them are carbohydrates in nature. We have explored the use of specific carbohydrate receptors for the functionalization of nanoparticles and demonstrated their binding specificities and their ability to mediate aggregations of targeted bacteria. Based on these binding specificities, here we report the development of adhensin-specific nanomechanical cantilever (microcantilever) biosensors for the detection of their targeted microorganisms.

Copyright © 2009 by ASME

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