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A Magnetic-Bead Based Microfluidic System for Automatic C-Reactive Protein Detection

[+] Author Affiliations
Wen-Bin Lee, Hsin-I Lin, Shu-Chu Shiesh, Gwo-Bin Lee

Cheng Kung University, Tainan, Taiwan

Paper No. MNHMT2009-18446, pp. 257-260; 4 pages
doi:10.1115/MNHMT2009-18446
From:
  • ASME 2009 Second International Conference on Micro/Nanoscale Heat and Mass Transfer
  • ASME 2009 Second International Conference on Micro/Nanoscale Heat and Mass Transfer, Volume 1
  • Shanghai, China, December 18–21, 2009
  • Conference Sponsors: Nanotechnology Institute
  • ISBN: 978-0-7918-4389-5 | eISBN: 978-0-7918-3864-8
  • Copyright © 2009 by ASME

abstract

C-reactive protein (CRP) has been used as a common indicator during inflammation process. It has been also reported that CRP concentration in serum can be used for risk assessment of cardiovascular diseases. In this study, a new microfluidic system for automatic measurement of CRP is developed. When compared to our previous work, the new chip can perform the entire measurement process by integrating a new micro-injector with other functional microfluidic devices. Experimental data show that the developed system can automate the entire process within 35 minutes with a high sensitivity. The development of the new system may provide a promising platform for automatic measurement of the CRP for point-of-care applications.

Copyright © 2009 by ASME

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