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Real-Time Measurement of Chemotherapeutic Drug Transport in an Individual Cancer Cell Selected in a Microfluidic Biochip

[+] Author Affiliations
Yuchun Chen, Paul C. H. Li

Simon Fraser University, Burnaby, BC, Canada

Paper No. MNHMT2009-18112, pp. 23-29; 7 pages
doi:10.1115/MNHMT2009-18112
From:
  • ASME 2009 Second International Conference on Micro/Nanoscale Heat and Mass Transfer
  • ASME 2009 Second International Conference on Micro/Nanoscale Heat and Mass Transfer, Volume 1
  • Shanghai, China, December 18–21, 2009
  • Conference Sponsors: Nanotechnology Institute
  • ISBN: 978-0-7918-4389-5 | eISBN: 978-0-7918-3864-8
  • Copyright © 2009 by ASME

abstract

Multidrug resistance (MDR) is a significant obstacle to effective chemotherapy to many patients. Because of the overexpression of one membrane protein, P-glycoprotein (P-gp), there is an increased efflux of chemotherapeutic drug in the resistant cancer cells. The main research goal of MDR study is to get improved intracellular drug retention inside the cancer cells. So it is important to study the chemotherapeutic drug transport in the cancer cells. In this work, single leukemia CEM MDR cell has been isolated and captured by a microfluidic single-cell biochip for drug transport and retention study.

Copyright © 2009 by ASME
Topics: Microfluidics , Cancer , Drugs

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