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A Multiphase Flow Simulation for a Cells-on-a-Chip Device

[+] Author Affiliations
Meihua Zhang, Amy Zheng, Z. Charlie Zheng, Zhuo Michael Wang

University of Kansas, Lawrence, KS

Paper No. IMECE2016-66126, pp. V007T09A041; 7 pages
doi:10.1115/IMECE2016-66126
From:
  • ASME 2016 International Mechanical Engineering Congress and Exposition
  • Volume 7: Fluids Engineering
  • Phoenix, Arizona, USA, November 11–17, 2016
  • Conference Sponsors: ASME
  • ISBN: 978-0-7918-5061-9
  • Copyright © 2016 by ASME

abstract

Microfluidics-based microscale cell culture (cells-on-a-chip) provides a well-controlled system with physiological realistic parameters that emulates the organ-to-organ network of the human body. In the microenvironment, the in vivo situation can be resembled closely by controlling the chip geometry, medium flow behavior, medium-to-cell ratio, and other fluid dynamic parameters. This study is to develop a multiphase model to simulate the flow in such a device. The cell deposition rate influenced by the flow shear is discussed. The physics of fluid dynamics for each of the above mentioned parameters is investigated.

Copyright © 2016 by ASME

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