Full Content is available to subscribers

Subscribe/Learn More  >

Modeling of Diffusive Behavior of Macromolecules Encapsulated in Electrospun Fibers

[+] Author Affiliations
Karen Chang Yan, Aren Moy, Michael Sebok

College of New Jersey, Ewing, NJ

Paper No. IMECE2016-67770, pp. V003T04A079; 5 pages
  • ASME 2016 International Mechanical Engineering Congress and Exposition
  • Volume 3: Biomedical and Biotechnology Engineering
  • Phoenix, Arizona, USA, November 11–17, 2016
  • Conference Sponsors: ASME
  • ISBN: 978-0-7918-5053-4
  • Copyright © 2016 by ASME


Electrospun (ES) fibers made of biocompatible polymers have been used as scaffolds in tissue engineering due to the potential to mimic the fibrous environment found in the extracellular matrix of biological tissue. Bioactive macromolecules such as growth factors have also been incorporated in the electrospun fibers to promote cell growth and differentiation. Therefore, it is critical to understand and control the release rate of the bioactive molecules. This paper presents the development of a stochastic simulation method to model the diffusive behaviors of macromolecules encapsulated in electrospun fibers. Specifically, a given ES fiber sample is represented by a set of random fibers with total fiber number denoted as N. Each fiber in the set is assumed as a cylinder and has a randomly assigned diameter and length, these parameters are based on statistical distributions determined from physical fiber samples. The Fick’s diffusion equation is used to solve the concentration of encapsulated macromolecules in the fiber due to diffusion. Upon obtaining the solution of the concentration of molecules in individual fibers, one can determine the overall diffusion behavior for a given sample with random fibers distributed. A subsequent statistical characterization can be performed based on the results of a set of random generated samples. Moreover, the developed method can be applied to the diffusion of macromolecules encapsulated in microspheres. The developed method was implemented in MATHEMATICA. As an example, the ES fiber samples were generated via electrospinning alginate and poly(ethylene oxide) (PEO) blend polymer aqueous solution (1:1 ratio, 3% w/v), and FITC–dextran was mixed in the polymer solution to enable fluorescent image analysis. The fiber diameter, length and number of fibers were determined based on the fluorescent images of fiber samples. Parametric study was conducted to examine how the diffusive behavior of encapsulated macromolecules is affected by the fiber diameters, total number of fibers, diffusion constants, and boundary conditions. Furthermore, the stochastic analyses were conducted for cases of the diffusion of macromolecules encapsulated in microspheres. The model predictions agree well with the experimental data obtained from the literature.

Copyright © 2016 by ASME



Interactive Graphics


Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging and repositioning the boxes below.

Related eBook Content
Topic Collections

Sorry! You do not have access to this content. For assistance or to subscribe, please contact us:

  • TELEPHONE: 1-800-843-2763 (Toll-free in the USA)
  • EMAIL: asmedigitalcollection@asme.org
Sign In