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Design of a Multifunctional Porous Coaxial Electrospun Mesh Using Polycaprolactone (PCL) and Poly Butylene Adipate-CO-Terephthalate (PBAT)

[+] Author Affiliations
Hussain R. Rizvi, Nandika D'Souza

University of North Texas, Denton, TX

Paper No. IMECE2016-67534, pp. V003T04A078; 6 pages
doi:10.1115/IMECE2016-67534
From:
  • ASME 2016 International Mechanical Engineering Congress and Exposition
  • Volume 3: Biomedical and Biotechnology Engineering
  • Phoenix, Arizona, USA, November 11–17, 2016
  • Conference Sponsors: ASME
  • ISBN: 978-0-7918-5053-4
  • Copyright © 2016 by ASME

abstract

In this paper, we formulate a method to create a potential drug delivery vehicle and scaffold architecture of coaxial electrospun fibers. Having the capability to introduce porosity either in core or sheath of the fiber using supercritical CO2 as a foaming agent is utilized. Polycaprolactone (PCL) and Poly butylene adipate-co-terephthalate (PBAT) were used because of their biodegradable and biocompatible nature. Physical morphology of the porous coaxial fibers was studied using Scanning Electron Microscopy (SEM), Image J software was used to quantify the pore size and fiber diameter. Dynamic Mechanical Analysis (DMA) and Tensile Testing of the three-dimensional fibrous mesh was done to determine the mechanical properties of the porous structure. Differential Scanning Calorimeter (DSC) was used to study the thermal characteristics of the mesh.

Copyright © 2016 by ASME

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