Full Content is available to subscribers

Subscribe/Learn More  >

Application of Hyperelastic Models in Mechanical Properties Prediction of Mouse Oocyte and Embryo Cells at Large Deformations

[+] Author Affiliations
Ali A. Abbasi, M. T. Ahmadian, Ali Alizadeh, S. Tarighi

Sharif University of Technology, Tehran, Iran

Paper No. IMECE2016-65034, pp. V003T04A021; 11 pages
  • ASME 2016 International Mechanical Engineering Congress and Exposition
  • Volume 3: Biomedical and Biotechnology Engineering
  • Phoenix, Arizona, USA, November 11–17, 2016
  • Conference Sponsors: ASME
  • ISBN: 978-0-7918-5053-4
  • Copyright © 2016 by ASME


Biological cell studies have many applications in biology, cell manipulation and diagnosis of diseases such as cancer and malaria. In this study, inverse finite element method (IFEM) combined with Levenberg-Marquardt optimization algorithm has been used to extract and characterize material properties of mouse oocyte and embryo cells at large deformations. Then, the simulation results have been validated using data from experimental works. In this study, it is assumed cell material is hyperelastic, isotropic, homogenous and axisymmetric. For inverse analysis, FEM model of cell injection experiment which implemented in Abaqus software has been coupled with Levenberg-Marquardt optimization algorithm written in Matlab; based on this coupling the optimum hyperelastic coefficients which give the best match between experimental and simulated forces are extracted. Results show that among different hyperelastic material models, Ogden material is well suitable for characterization of mouse oocyte cell and Mooney-Rivlin or polynomial are suitable for characterization of mouse embryo cell. Moreover the evaluated Poisson ratio of the cell is obtained to be equal to 0.5, which indicates the structural material of mouse oocyte and embryo, are compressible.

Copyright © 2016 by ASME



Interactive Graphics


Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging and repositioning the boxes below.

Related eBook Content
Topic Collections

Sorry! You do not have access to this content. For assistance or to subscribe, please contact us:

  • TELEPHONE: 1-800-843-2763 (Toll-free in the USA)
  • EMAIL: asmedigitalcollection@asme.org
Sign In