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System for In Vivo Nanoinjection of Tissues

[+] Author Affiliations
Talmage H. Jones, Brian D. Jensen

Brigham Young University, Provo, UT

Paper No. DETC2016-60033, pp. V004T08A002; 6 pages
doi:10.1115/DETC2016-60033
From:
  • ASME 2016 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference
  • Volume 4: 21st Design for Manufacturing and the Life Cycle Conference; 10th International Conference on Micro- and Nanosystems
  • Charlotte, North Carolina, USA, August 21–24, 2016
  • Conference Sponsors: Design Engineering Division, Computers and Information in Engineering Division
  • ISBN: 978-0-7918-5014-5
  • Copyright © 2016 by ASME

abstract

This paper investigates the design of a nano-injection system that can deliver genetic material to cells within live tissue. The approach to creating such a system was to create candidate designs that meet all the requirements for successful in vivo injection and can be fabricated using silicon etching. The designs were tested through large-scale prototyping and through models that describe the systems’ behavior on the micrometer scale. One design consists of an array of lances on a rigid backing. The other design consists of an array of lances grouped in sets of three on a backing that can conform to the shape of the tissue being injected. Each design was prototyped in 3D printed ABS plastic. Preliminary results were qualitative and showed that the rigid and flexible designs performed similarly on mostly flat and irregular surfaces. On convex surfaces with a strong curvature (radius of curvature of about 2 cm), the flexible array gave slightly better results. Final testing gave a quantitative comparison of the two designs’ efficiencies on strongly curved convex surfaces. These results supported the preliminary results that the flexible array is more efficient in reaching points on the tissue than the rigid array is. As the applied force increased, each array performed more efficiently.

Copyright © 2016 by ASME

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