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Numerical Simulation of Insulin Depot Formation in Subcutaneous Tissue

[+] Author Affiliations
Michael M. Zedelmair, Abhijit Mukherjee

California State University of Northridge, Northridge, CA

Paper No. FEDSM2016-7719, pp. V01AT03A015; 7 pages
doi:10.1115/FEDSM2016-7719
From:
  • ASME 2016 Fluids Engineering Division Summer Meeting collocated with the ASME 2016 Heat Transfer Summer Conference and the ASME 2016 14th International Conference on Nanochannels, Microchannels, and Minichannels
  • Volume 1A, Symposia: Turbomachinery Flow Simulation and Optimization; Applications in CFD; Bio-Inspired and Bio-Medical Fluid Mechanics; CFD Verification and Validation; Development and Applications of Immersed Boundary Methods; DNS, LES and Hybrid RANS/LES Methods; Fluid Machinery; Fluid-Structure Interaction and Flow-Induced Noise in Industrial Applications; Flow Applications in Aerospace; Active Fluid Dynamics and Flow Control — Theory, Experiments and Implementation
  • Washington, DC, USA, July 10–14, 2016
  • Conference Sponsors: Fluids Engineering Division
  • ISBN: 978-0-7918-5028-2
  • Copyright © 2016 by ASME

abstract

In this study a numerical model of the insulin depot formation and absorption in the subcutaneous adipose tissue is developed using the commercial Computational Fluid Dynamics (CFD) software ANSYS Fluent. A better understanding of these mechanisms can be helpful in the development of new devices and cannula geometries as well as predicting the concentration of insulin in the blood. The injection method considered in this simulation is by the use of an insulin pump using a rapid acting U100 insulin analogue. The insulin is injected into the subcutaneous tissue in the abdominal region. The main composition of the subcutaneous tissue is blood vessels and adipose cells surrounded by interstitial fluid. The numerical simulation is conducted in a 2D-axisymmetric domain where the tissue is modeled as a fluid saturated porous media. Due to the presence of channel formation in lateral direction in the tissue, an anisotropic approach to define the permeability is studied having an impact on the viscous resistance to the flow. This configuration is resulting in a rather disk shaped depot following recent experimental findings. The depot formation is analyzed running Bolus injections ranging from 5–15 Units of insulin corresponding to 50–150μl. The depot formation model has been extended implementing the process of absorption of insulin from the depot to be able to run the simulation over longer timeframes where absorption starts playing an important role.

Copyright © 2016 by ASME

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