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Tumor Shrinkage Study in Magnetic Nanoparticle Hyperthermia Based on Designed Heating Protocols

[+] Author Affiliations
Alexander LeBrun, Ronghui Ma, Liang Zhu

University of Maryland Baltimore County, Baltimore, MD

Paper No. MNHMT2016-6559, pp. V002T13A006; 4 pages
  • ASME 2016 5th International Conference on Micro/Nanoscale Heat and Mass Transfer
  • Volume 2: Micro/Nano-Thermal Manufacturing and Materials Processing; Boiling, Quenching and Condensation Heat Transfer on Engineered Surfaces; Computational Methods in Micro/Nanoscale Transport; Heat and Mass Transfer in Small Scale; Micro/Miniature Multi-Phase Devices; Biomedical Applications of Micro/Nanoscale Transport; Measurement Techniques and Thermophysical Properties in Micro/Nanoscale; Posters
  • Biopolis, Singapore, January 4–6, 2016
  • Conference Sponsors: Heat Transfer Division
  • ISBN: 978-0-7918-4966-8
  • Copyright © 2016 by ASME


Magnetic nanoparticle hyperthermia has attracted growing attentions recently due to its ability of confining nanoparticle-induced heating in targeted tumor region. Our recent studies have identified an injection strategy to achieve repeatable and controllable nanoparticle deposition patterns in PC3 tumors using microCT scans. Based on the injection strategy, simulation of temperature elevations in tumors is conducted to design heating protocols to induce irreversible thermal damage to the entire tumors. In this study, in vivo heating experiments are performed on PC3 tumors implanted on mice following the designed heating protocols. The tumors in the control group without heating triple their sizes over a period of eight weeks. The tumors in the heating groups are heated for either 25 minutes or 12 minutes, representing that the Arrhenius integral is equal to or larger than 4 or 1 in the entire tumors, respectively. The tumors in the heating group of 25 minutes disappear completely after the 3rd days, and the site maintains the disappearance for over eight weeks. The sizes of the tumors in the heating group of 12 minutes decrease in the first ten days, however, the tumors re-grow afterwards, and by the end of the 8th week, they are approximately 60% larger than their initial size. This study demonstrates the importance of imaging-based design for individualized treatment planning. The success of the designed heating protocol in complete damaging PC3 tumors validates the theoretical models used in planning the heating treatment in magnetic nanoparticle hyperthermia.

Copyright © 2016 by ASME



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