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Design of a MRI-Visible and Radiopaque Drug Delivery Coating for Bioresorbable Stents

[+] Author Affiliations
Amy C. Goodfriend, Tré R. Welch, Jian Wang, Romaine F. Johnson, Chet C. Xu, Surendranath R. Veeram Reddy, Alan Nugent, James Richardson, Joseph M. Forbess

University of Texas Southwestern Medical Center at Dallas, Dallas, TX

Kytai T. Nguyen

University of Texas at Arlington, Arlington, TX

Paper No. IMECE2015-52146, pp. V003T03A031; 10 pages
doi:10.1115/IMECE2015-52146
From:
  • ASME 2015 International Mechanical Engineering Congress and Exposition
  • Volume 3: Biomedical and Biotechnology Engineering
  • Houston, Texas, USA, November 13–19, 2015
  • Conference Sponsors: ASME
  • ISBN: 978-0-7918-5738-0
  • Copyright © 2015 by ASME

abstract

Cardiovascular stents are currently being used for intraluminal stenting of the trachea for tracheomalacia treatment. These devices composed of permanent materials are controversial due to their limitations at internal reinforcement and biocompatibility, especially in pediatrics. We show in a pediatric tracheomalacia rabbit model, a poly-L-lactic acid (PLLA) Double Opposed Helical bioresorbable stent (DH) elicits a more mild inflammatory response in the malacic airway compared to a control metal stent. To further improve efficacy, a multi-drug delivery, bioresorbable coating was designed. The coating design controllably delivers ciprofloxacin (antibiotic) for one week and dexamethasone (anti-inflammatory agent) for three months. The bioresorbable polymeric components also demonstrate feasible visibility utilizing Magnetic Resonance Imaging (MRI). The local multi-drug delivery and imaging capabilities in this coating design in combination with the bioresorbable DH stent will result in a successful intervention specifically design for pediatric tracheomalacia. This design will eliminate long-term risks associated with current permanent devices and provide necessary theranostic agents to facilitate healing and monitor progress via non-invasive imaging techniques.

Copyright © 2015 by ASME

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