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Characterization of a Microfabricated Differential Scanning Calorimeter

[+] Author Affiliations
Shuyu Wang, Shifeng Yu

State University of New York at Stony Brook, Stony Brook, NY

Lei Zuo

State University of New York at Stony Brook, Stony Brook, NYVirginia Tech, Blacksburg, VA

Paper No. DETC2015-46136, pp. V004T09A002; 6 pages
doi:10.1115/DETC2015-46136
From:
  • ASME 2015 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference
  • Volume 4: 20th Design for Manufacturing and the Life Cycle Conference; 9th International Conference on Micro- and Nanosystems
  • Boston, Massachusetts, USA, August 2–5, 2015
  • Conference Sponsors: Design Engineering Division, Computers and Information in Engineering Division
  • ISBN: 978-0-7918-5711-3
  • Copyright © 2015 by ASME

abstract

Calorimeters are critical tools for structural based drug design and drug stability assessment. Current pharmaceutical industry is seeking for high throughput calorimeters to reduce the research time and expenditure. MEMS-based calorimeter is a potential solution for it, since they are miniaturized to detect the enthalpy change during macro molecular interaction with smaller amount of samples, shorter time and could easily enable parallel measurement. Consequently, we present a Differential Scanning Calorimeter (DSC) that requires 2μL sample volume. It has high thermal insulation (1210μW/K), small time constant (6.95s) and high sensitivity (7.5V/W). The low noise equivalent temperature difference (NETD) could lead to 130nW of power resolution. These characterization results indicate the device could be potentially applied for macromolecular interaction application and increase the throughput with high performance.

Copyright © 2015 by ASME

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