Full Content is available to subscribers

Subscribe/Learn More  >

In Vivo Testing of Noninvasive ICP Monitoring Methodology in a Porcine Model

[+] Author Affiliations
Jeff A. Hawks, Chase Pfeifer, Max Twedt, Greg Bashford

University of Nebraska, Lincoln, NE

William Thorell, James Gigantelli

University of Nebraska Medical Center, Omaha, NE

Paper No. DETC2015-47655, pp. V003T14A013; 7 pages
  • ASME 2015 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference
  • Volume 3: 17th International Conference on Advanced Vehicle Technologies; 12th International Conference on Design Education; 8th Frontiers in Biomedical Devices
  • Boston, Massachusetts, USA, August 2–5, 2015
  • Conference Sponsors: Design Engineering Division, Computers and Information in Engineering Division
  • ISBN: 978-0-7918-5710-6
  • Copyright © 2015 by ASME


Research has suggested that elevated intracranial pressure (ICP) can cause damage to the optic nerve and reduce visual acuity. There is a need for noninvasive ICP monitoring devices. A simple, portable device capable of measuring relative changes in ICP using a noninvasive methodology would have a significant impact on clinical care. The methodology presented in this paper utilizes transcranial Doppler ultrasonography to monitor ophthalmic artery hemodynamics while small forces are applied to cornea. In vivo testing using a porcine model results in a correlation between pulsatility or resistivity indices and ICP levels. Specifically, the change in these indices while force is applied decreases as ICP increases. The data collection prototype used in these experiments contained an ultrasound transducer instrumented with a load cell to measure force applied to the cornea. These experiments are an initial step towards adapting the data collection prototype into a handheld noninvasive ICP monitoring device.

Copyright © 2015 by ASME
Topics: Testing



Interactive Graphics


Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging and repositioning the boxes below.

Related eBook Content
Topic Collections

Sorry! You do not have access to this content. For assistance or to subscribe, please contact us:

  • TELEPHONE: 1-800-843-2763 (Toll-free in the USA)
  • EMAIL: asmedigitalcollection@asme.org
Sign In