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Low-Cost Label-Free Bio-Detection System Using Double-Sided Grating Waveguide Couplers

[+] Author Affiliations
Yi-Fan Ku, Hsun-Yuan Li, Yu-Chung Lin, Wen-Hsin Hsieh, Guo-En Chang

National Chung Cheng University, Chia-Yi County, Taiwan

Paper No. DETC2015-46296, pp. V003T14A007; 5 pages
  • ASME 2015 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference
  • Volume 3: 17th International Conference on Advanced Vehicle Technologies; 12th International Conference on Design Education; 8th Frontiers in Biomedical Devices
  • Boston, Massachusetts, USA, August 2–5, 2015
  • Conference Sponsors: Design Engineering Division, Computers and Information in Engineering Division
  • ISBN: 978-0-7918-5710-6
  • Copyright © 2015 by ASME


Low-cost label-free bio-sensing systems have long been desired to enable rapid, sensitive, quantitative, and high-throughput biosensing for bio-medical and chemical applications. Here we present an optical bio-detection system consists of injection-molded biosensors based on double-sided grating waveguide couplers and an optical intensity-based detection platform for low-cost, real-time, and label-free biosensing. The biosensors were fabricated combining injection-molding and sputtering techniques, providing unique advantages of low-cost and reduced production time. A simple and cost-effective optical intensity-based detection system employing a low-cost light emitting diode and a simple photodetector is also developed to perform label-free biosensing. We demonstrate that a high refractive index resolution of 6.43 × 10−5 RIU is achieved with this compact bio-sensing system, showing great promises for low-cost, real-time, label-free detection in bio-medical and chemical applications.

Copyright © 2015 by ASME



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