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A Control-Oriented Model of Blood Volume Response to Hemorrhage and Fluid Resuscitation

[+] Author Affiliations
Ramin Bighamian, Jin-Oh Hahn

University of Maryland, College Park, MD

Andrew T. Reisner

Massachusetts General Hospital, Boston, MA

Paper No. DSCC2015-9847, pp. V001T16A004; 6 pages
  • ASME 2015 Dynamic Systems and Control Conference
  • Volume 1: Adaptive and Intelligent Systems Control; Advances in Control Design Methods; Advances in Non-Linear and Optimal Control; Advances in Robotics; Advances in Wind Energy Systems; Aerospace Applications; Aerospace Power Optimization; Assistive Robotics; Automotive 2: Hybrid Electric Vehicles; Automotive 3: Internal Combustion Engines; Automotive Engine Control; Battery Management; Bio Engineering Applications; Biomed and Neural Systems; Connected Vehicles; Control of Robotic Systems
  • Columbus, Ohio, USA, October 28–30, 2015
  • Conference Sponsors: Dynamic Systems and Control Division
  • ISBN: 978-0-7918-5724-3
  • Copyright © 2015 by ASME


This paper presents a control-oriented model of blood volume response to hemorrhage and fluid resuscitation that can be potentially utilized in closed-loop control of fluid resuscitation. A unique characteristic of the proposed model is that it is built to ensure structural parsimony while retaining physiological transparency. To accomplish this characteristic, blood volume regulation in the body to external perturbations of hemorrhage and fluid resuscitation was modeled as a low-order control system in which the fluid transfer between blood and interstitial fluid is governed by a proportional-integral controller. This in essence resulted in a minimal model with four parameters to be adapted to each individual. The validity of the proposed model was tested using data available in the literature. The results indicated that the proposed model was able to reproduce the blood volume response to hemorrhage and fluid resuscitation with high fidelity: on the average, the prediction error was only 1.53 ± 11.5 %, thus strongly supporting our claim that it can be used as viable basis for the design of closed-loop fluid resuscitation controllers.

Copyright © 2015 by ASME
Topics: Fluids , Blood



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