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Optimizing Ultrafiltration Rate Profiles for the Estimation of Blood Volume During Hemodialysis

[+] Author Affiliations
C. V. Hollot, J. Horowitz, Y. Chait

UMass, Amherst, MA

R. P. Shrestha

Octet Research Inc., Boston, MA

M. G. Germain

Western New England Renal & Transplant Associates, PC, Springfield, MA

Paper No. DSCC2015-9725, pp. V001T16A003; 5 pages
  • ASME 2015 Dynamic Systems and Control Conference
  • Volume 1: Adaptive and Intelligent Systems Control; Advances in Control Design Methods; Advances in Non-Linear and Optimal Control; Advances in Robotics; Advances in Wind Energy Systems; Aerospace Applications; Aerospace Power Optimization; Assistive Robotics; Automotive 2: Hybrid Electric Vehicles; Automotive 3: Internal Combustion Engines; Automotive Engine Control; Battery Management; Bio Engineering Applications; Biomed and Neural Systems; Connected Vehicles; Control of Robotic Systems
  • Columbus, Ohio, USA, October 28–30, 2015
  • Conference Sponsors: Dynamic Systems and Control Division
  • ISBN: 978-0-7918-5724-3
  • Copyright © 2015 by ASME


Knowledge of a patient’s blood volume during hemodialysis is important as removing too much or too little fluid or removing it too fast has been associated with increased patient morbidity and mortality. Non-invasive absolute blood volume measurements are currently not available. We show how to estimate initial absolute blood volume from readily available relative blood volume measurements, but, in addition that blood volume estimates under present clinical practice will have high variance. We derive D-optimal ultrafiltration profiles for estimation of an individual’s initial blood volume, and demonstrate their performance by simulation.

Copyright © 2015 by ASME
Topics: Blood , Hemodialysis



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