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Prediction of Periventricular Leukomalacia Occurrence in Neonates Using a Novel Support Vector Machine Classifier Optimization Method

[+] Author Affiliations
Dieter Bender, Ali Jalali, C. Nataraj

Villanova University, Villanova, PA

Daniel J. Licht

Children’s Hospital of Philadelphia, Philadelphia, PA

Paper No. DSCC2015-9984, pp. V001T15A005; 7 pages
  • ASME 2015 Dynamic Systems and Control Conference
  • Volume 1: Adaptive and Intelligent Systems Control; Advances in Control Design Methods; Advances in Non-Linear and Optimal Control; Advances in Robotics; Advances in Wind Energy Systems; Aerospace Applications; Aerospace Power Optimization; Assistive Robotics; Automotive 2: Hybrid Electric Vehicles; Automotive 3: Internal Combustion Engines; Automotive Engine Control; Battery Management; Bio Engineering Applications; Biomed and Neural Systems; Connected Vehicles; Control of Robotic Systems
  • Columbus, Ohio, USA, October 28–30, 2015
  • Conference Sponsors: Dynamic Systems and Control Division
  • ISBN: 978-0-7918-5724-3
  • Copyright © 2015 by ASME


Prior work has documented that Support Vector Machine (SVM) classifiers can be powerful tools in predicting clinical outcomes of complex diseases such as Periventricular Leukomalacia (PVL). Our previous study showed that SVM performance can be improved significantly by optimizing the supervised training set used during the learning stage of the overall SVM algorithm. This study fully develops the initial idea using the reliable Leave-One-Out Cross-validation (LOOCV) technique. The work presented in this paper confirms previous results and improves the performance of the SVM even further. In addition, using the LOOCV technique, the computational time is decreased and the structure of the algorithm simplified, making this framework more feasible. Furthermore, we evaluate the performance of the resulting optimized SVM classifier on an unseen set of data. This demonstrates that the developed SVM algorithm outperforms normal SVM type classifiers without any loss of generalization.

Copyright © 2015 by ASME



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