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A Review of Bone Graft Substitutes Made From HA-Polymer Composite Scaffolds and Fabrication Potential With Laser-Based Additive Manufacturing Processes

[+] Author Affiliations
Hera Wu, Shuting Lei

Kansas State University, Manhattan, KS

Paper No. MSEC2015-9366, pp. V001T02A107; 11 pages
doi:10.1115/MSEC2015-9366
From:
  • ASME 2015 International Manufacturing Science and Engineering Conference
  • Volume 1: Processing
  • Charlotte, North Carolina, USA, June 8–12, 2015
  • Conference Sponsors: Manufacturing Engineering Division
  • ISBN: 978-0-7918-5682-6
  • Copyright © 2015 by ASME

abstract

Hydroxyapatite, a bioactive ceramic, has been combined with biodegradable polymers to create composite three-dimensional interconnected porous scaffolds for bone graft substitutes. The materials and fabrication methods of these composite scaffolds are reviewed. The resulting mechanical and biological properties of scaffolds produced from the combination of certain materials and fabrication methods are analyzed. Requirements for a bone graft substitute and third generation scaffolds with the addition of osteoinductive and osteogenic features to composite scaffolds including biomolecule delivery and cell seeding are also introduced. Finally, the benefits of using additive manufacturing technologies to enable high level of control over the design of interconnected pore structure are discussed.

Copyright © 2015 by ASME

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