0

Full Content is available to subscribers

Subscribe/Learn More  >

Biomechanical Effects of Kaempferol Treatments on the Bone Healing Process of Murine Tibia

[+] Author Affiliations
Hanjong Kim, Changwan Han, Seonghun Park

Pusan National University, Busan, Korea

Otgonbayar Maidar, Sang-Soo Lee

Hallym University, Chuncheon, Korea

Paper No. IMECE2014-37810, pp. V014T11A023; 3 pages
doi:10.1115/IMECE2014-37810
From:
  • ASME 2014 International Mechanical Engineering Congress and Exposition
  • Volume 14: Emerging Technologies; Engineering Management, Safety, Ethics, Society, and Education; Materials: Genetics to Structures
  • Montreal, Quebec, Canada, November 14–20, 2014
  • Conference Sponsors: ASME
  • ISBN: 978-0-7918-4963-7
  • Copyright © 2014 by ASME

abstract

Kaempferol is a typical flavonol-type flavonoid and has a protective effect on postmenopausal bone loss, and previous studies have reported that kaempferol treated groups show an increase in the callus size and bone mineral density as well as improvement in biomechanical behaviors in comparison with untreated control groups in the bone healing process. The present study aims at investigating the effect of kaempferol treatments on fractured murine tibia, by measuring kaempferol dose-dependent mechanical properties in the bone healing process of murine tibia fracture models.

A stabilized fracture was generated at tibia by minor modification of the Hiltunen method for 8 weeks old ICR mice weighting 29.0 ∼ 30.5 g. Experimental mice were divided into 4 groups. Kaempferol of 0.2, 1.0, 5.0 mg/kg (body weight) with 20 % ethanol was administered to 3 groups and the remaining one group was only treated with 20 % ethanol as a control group. Three-point bending fracture tests were conducted to measure the mechanical properties (fracture load, fracture energy, stiffness) of murine tibiae at non-fractured regions near fracture sites 21 days after kaempferol treatments, via a custom-made biomechanical testing system (BTS, KST Co., Korea).

The 5.0 mg/kg kaempferol treated group shows higher fracture load (20.54 ±5.04 N) than the control group (17.82 ±5.94 N). Fracture energy, total energy applied to tibia up to bone fracture, exhibited no significant differences between the control group and any of the kampferol treated groups, although both the 1.0 mg/kg kaempferol treated and control groups showed a little higher fracture energy than the 0.2 and 5.0 mg/kg kaempferol treated groups. Bone stiffness also did not show statistically significant differences between the control group and any of the kaempferol treated groups, with the highest stiffness value observed in the 1.0 mg/kg kaempferol treated group.

Copyright © 2014 by ASME
Topics: Biomechanics , Bone

Figures

Tables

Interactive Graphics

Video

Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging and repositioning the boxes below.

Related eBook Content
Topic Collections

Sorry! You do not have access to this content. For assistance or to subscribe, please contact us:

  • TELEPHONE: 1-800-843-2763 (Toll-free in the USA)
  • EMAIL: asmedigitalcollection@asme.org
Sign In