Full Content is available to subscribers

Subscribe/Learn More  >

Lumped Thermal Model of a Newborn Lamb and a Liquid Ventilator in Total Liquid Ventilation

[+] Author Affiliations
Mathieu Nadeau, Philippe Micheau, Raymond Robert, Jonathan Vandamme, Julien Mousseau, Olivier Avoine, Pamela Samanta Germim, Michaël Sage, Jean-Paul Praud, Hervé Walti

Université de Sherbrooke, Sherbrooke, QC, Canada

Renaud Tissier

Institut National de la Santé et de la Recherche Médicale, Créteil, France

Paper No. IMECE2014-40108, pp. V003T03A078; 9 pages
  • ASME 2014 International Mechanical Engineering Congress and Exposition
  • Volume 3: Biomedical and Biotechnology Engineering
  • Montreal, Quebec, Canada, November 14–20, 2014
  • Conference Sponsors: ASME
  • ISBN: 978-0-7918-4646-9
  • Copyright © 2014 by ASME


Total liquid ventilation (TLV) is an emerging and promising mechanical ventilation method in which the lungs are filled with a breathable liquid. Perfluorocarbon (PFC) is the predominant liquid of choice due to its high O2 and CO2 solubility. In TLV, a dedicated liquid ventilator ensures gas exchange by renewing a tidal volume of PFC, which is temperature-controlled, oxygenated and free of CO2. A fundamental difference between TLV and conventional mechanical ventilation relates to the fact that PFCs are approximately 1500 times denser than air. This high density provides PFCs with a large heat capacity, turning the lungs into an efficient heat exchanger with circulating blood. The originality of this study is the development of a lumped thermal model of the body as a heat exchanger coupled to a liquid ventilator. The model was validated with an animal experimentation on a newborn lamb with the Inolivent-5.0 liquid ventilator prototype. TLV was initiated with a fast hypothermia induction, followed successively by a slow posthypothermic rewarming, a fast rewarming and finally a second fast hypothermia induction. Results demonstrate that the model was able to aptly predict, in every phase, the temperature of the lungs, the eardrum, the rectum as well as the various compartments of the liquid ventilator.

Copyright © 2014 by ASME
Topics: Ventilation



Interactive Graphics


Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging and repositioning the boxes below.

Related eBook Content
Topic Collections

Sorry! You do not have access to this content. For assistance or to subscribe, please contact us:

  • TELEPHONE: 1-800-843-2763 (Toll-free in the USA)
  • EMAIL: asmedigitalcollection@asme.org
Sign In