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Lumped Thermal Model of a Newborn Lamb and a Liquid Ventilator in Total Liquid Ventilation

[+] Author Affiliations
Mathieu Nadeau, Philippe Micheau, Raymond Robert, Jonathan Vandamme, Julien Mousseau, Olivier Avoine, Pamela Samanta Germim, Michaël Sage, Jean-Paul Praud, Hervé Walti

Université de Sherbrooke, Sherbrooke, QC, Canada

Renaud Tissier

Institut National de la Santé et de la Recherche Médicale, Créteil, France

Paper No. IMECE2014-40108, pp. V003T03A078; 9 pages
doi:10.1115/IMECE2014-40108
From:
  • ASME 2014 International Mechanical Engineering Congress and Exposition
  • Volume 3: Biomedical and Biotechnology Engineering
  • Montreal, Quebec, Canada, November 14–20, 2014
  • Conference Sponsors: ASME
  • ISBN: 978-0-7918-4646-9
  • Copyright © 2014 by ASME

abstract

Total liquid ventilation (TLV) is an emerging and promising mechanical ventilation method in which the lungs are filled with a breathable liquid. Perfluorocarbon (PFC) is the predominant liquid of choice due to its high O2 and CO2 solubility. In TLV, a dedicated liquid ventilator ensures gas exchange by renewing a tidal volume of PFC, which is temperature-controlled, oxygenated and free of CO2. A fundamental difference between TLV and conventional mechanical ventilation relates to the fact that PFCs are approximately 1500 times denser than air. This high density provides PFCs with a large heat capacity, turning the lungs into an efficient heat exchanger with circulating blood. The originality of this study is the development of a lumped thermal model of the body as a heat exchanger coupled to a liquid ventilator. The model was validated with an animal experimentation on a newborn lamb with the Inolivent-5.0 liquid ventilator prototype. TLV was initiated with a fast hypothermia induction, followed successively by a slow posthypothermic rewarming, a fast rewarming and finally a second fast hypothermia induction. Results demonstrate that the model was able to aptly predict, in every phase, the temperature of the lungs, the eardrum, the rectum as well as the various compartments of the liquid ventilator.

Copyright © 2014 by ASME
Topics: Ventilation

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