0

Full Content is available to subscribers

Subscribe/Learn More  >

Model of Drug Delivery to the Eye

[+] Author Affiliations
Maryam Shafahi, Parham Piroozan

California State Polytechnic University, Pomona, CA

Paper No. IMECE2014-39438, pp. V003T03A077; 4 pages
doi:10.1115/IMECE2014-39438
From:
  • ASME 2014 International Mechanical Engineering Congress and Exposition
  • Volume 3: Biomedical and Biotechnology Engineering
  • Montreal, Quebec, Canada, November 14–20, 2014
  • Conference Sponsors: ASME
  • ISBN: 978-0-7918-4646-9
  • Copyright © 2014 by ASME

abstract

Ocular diseases cause vision deficiency and blindness in a substantial number of people in the world every day. Therefore, a controlled and sustained system of drug delivery to a specific spot within the eye is of interest for the ophthalmology community. The unique and complicated anatomy, physiology, and biochemistry of the eye make this organ highly resistant to drug delivery systems. The major challenge is to improve the efficiency of each treatment method along with avoiding the invasive techniques which damage the eye’s protective barrier tissues. In this work we make a computer model for the drug delivery to the anterior sections of the eye and provide a summary of transport characteristics of the eye, pharmacokinetics and efficacy of the utilized drugs. A two dimensional finite element model is utilized to solve the conservation of mass and momentum equations within different eye sub-domains such as cornea, anterior chamber, iris and sclera. The commercial software Comsol Multiphysics was utilized to obtain the profile of concentration in the eye and the grid independency of the numerical results has been checked. The results are being shown in terms of transient drug concentration profile in the eye subdomains. The influence of the modeling parameters on the efficiency of the drug delivery system is studied. The effect of physical variables such as drug molecular size and its bioavailability are investigated. The results are compared with the available literature data which are based on the drug diffusion within the domain.

Copyright © 2014 by ASME

Figures

Tables

Interactive Graphics

Video

Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging and repositioning the boxes below.

Related eBook Content
Topic Collections

Sorry! You do not have access to this content. For assistance or to subscribe, please contact us:

  • TELEPHONE: 1-800-843-2763 (Toll-free in the USA)
  • EMAIL: asmedigitalcollection@asme.org
Sign In