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Virtual Airway Pressure and Lung Temperature Sensors in a Total Liquid Ventilation Connector

[+] Author Affiliations
Raymond Robert, Philippe Micheau, Mathieu Nadeau, Jonathan Vandamme, Julien Mousseau, Olivier Avoine, Michael Sage, Jean-Paul Praud, Hervé Walti

Université de Sherbrooke, Sherbrooke, QC, Canada

Paper No. IMECE2014-40070, pp. V003T03A047; 9 pages
  • ASME 2014 International Mechanical Engineering Congress and Exposition
  • Volume 3: Biomedical and Biotechnology Engineering
  • Montreal, Quebec, Canada, November 14–20, 2014
  • Conference Sponsors: ASME
  • ISBN: 978-0-7918-4646-9
  • Copyright © 2014 by ASME


Total liquid ventilation (TLV) is an experimental mechanical ventilation technique where the lungs are completely filled with a perfluorocarbon liquid (PFC). It can be used to implement moderate therapeutic hypothermia (MTH) and treat severe respiratory problems. During TLV, the airway pressure must be monitored adequately to avoid overpressure and airway collapses. On the thermodynamic level, rectal, esophageal or tympanic temperature measurements are not suitable (long time constant) to avoid lowering the heart below 30°C. The objective was to design a Y connector positioned at the mouth which integrates the virtual sensors, used by controllers. The first estimates the airway pressure and the second provides the core body temperature. Pressure and RTD sensors were installed in the connector to implement the virtual measurements. In-vitro experiments were done to validate the virtual sensors. In-vivo experiments (on newborn lambs) confirm the accuracy of the airway pressure estimation and of the systemic arterial temperature.

Copyright © 2014 by ASME



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