0

Full Content is available to subscribers

Subscribe/Learn More  >

A Sensitive Multiparametric Biosensor With Capabilities of Rapid Toxicity Detection of Drinking Water

[+] Author Affiliations
Fei Liu, Ioana Voiculescu

City College of New York, New York, NY

Anis N. Nordin

International Islamic University Malaysia, Kuala Lumpur, Malaysia

Fang Li

New York Institute of Technology, Old Westbury, NY

Paper No. IMECE2013-62281, pp. V010T11A001; 4 pages
doi:10.1115/IMECE2013-62281
From:
  • ASME 2013 International Mechanical Engineering Congress and Exposition
  • Volume 10: Micro- and Nano-Systems Engineering and Packaging
  • San Diego, California, USA, November 15–21, 2013
  • Conference Sponsors: ASME
  • ISBN: 978-0-7918-5639-0
  • Copyright © 2013 by ASME

abstract

Recently, there has been interest to develop biosensors based on live mammalian cells to monitor the toxicity of water. The cell viability after exposure to toxic water can be monitored by electric cell-substrate impedance sensing (ECIS) of the cell membrane. However, these impedance based toxicity sensors can only provide one single sensing endpoint (impedance measurement), and many toxicants cannot be detected at the concentration between Military Exposure Guideline levels and estimated Human Lethal Concentrations. The goal of this paper is to provide a rapid and sensitive sensing platform for long-term water toxicity detection. In this paper a novel multiparametric biosensor with integrated microfluidic channels for water toxicity detection is presented. Toxicity tests to study bovine aortic endothelial cells (BAECs) responsiveness to health-threatening concentrations of ammonia in de-ionized (DI) water will be presented. We demonstrated the BAECs can rapidly respond to ammonia concentrations between the military exposure guideline of 2mM and human lethal concentration of 55mM. The successful testing of water toxicity by simultaneous gravimetric and impedimetric measurements indicates that the multiparametric biosensor platform is able to perform rapid and sensitive detection of water toxicity and minimize the false-positive rate.

Copyright © 2013 by ASME
Topics: Biosensors , Water

Figures

Tables

Interactive Graphics

Video

Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging and repositioning the boxes below.

Related eBook Content
Topic Collections

Sorry! You do not have access to this content. For assistance or to subscribe, please contact us:

  • TELEPHONE: 1-800-843-2763 (Toll-free in the USA)
  • EMAIL: asmedigitalcollection@asme.org
Sign In