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Dynamic Particle Concentration for Bio-Signal Enhancement Based on an Optoelectric Microchip

[+] Author Affiliations
Kuan-Chih Wang, Han-Sheng Chuang

National Cheng Kung University, Tainan, Taiwan

Steven T. Wereley

Purdue University, West Lafayette, IN

Aloke Kumar

University of Alberta, Edmonton, AB, Canada

Paper No. IMECE2013-62329, pp. V07BT08A001; 3 pages
doi:10.1115/IMECE2013-62329
From:
  • ASME 2013 International Mechanical Engineering Congress and Exposition
  • Volume 7B: Fluids Engineering Systems and Technologies
  • San Diego, California, USA, November 15–21, 2013
  • Conference Sponsors: ASME
  • ISBN: 978-0-7918-5632-1
  • Copyright © 2013 by ASME

abstract

Concentration is a vital measure to collect samples in biology. The same measure can also benefit bio-signal enhancement. Conventionally, signal detection heavily relies on the sensitivity of sensors. However, background noise usually interferes with the accuracy as the sample concentration level is below a threshold. The signals are even weaker especially in miniaturized diagnostics or point-of-care devices. Alternatively, single cell/molecule detection[1] was developed to break the engineering limitation and achieve better detectability. However, challenge concerning to single cell/molecule capturing and manipulation is a potential barrier in the field. In addition, the effectiveness of sampling remains an open quest under study. As a result, concentrating samples provides a simple, rapid, and direct means for enhancing weak bio-signal detection.

Copyright © 2013 by ASME

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