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Active and Passive Responses of Myofibroblasts in Response to Mechanical Stretching in 3D Culture

[+] Author Affiliations
Adam C. Nathan, Sheng-Lin Lee, Tao Ju, Kenneth M. Pryse, Elliot L. Elson, Guy M. Genin

Washington University in St. Louis, St. Louis, MO

J. Pablo Marquez

University of Medicine and Dentistry of New Jersey, Newark, NJ

Paper No. SBC2008-193101, pp. 649-650; 2 pages
doi:10.1115/SBC2008-193101
From:
  • ASME 2008 Summer Bioengineering Conference
  • ASME 2008 Summer Bioengineering Conference, Parts A and B
  • Marco Island, Florida, USA, June 25–29, 2008
  • Conference Sponsors: Bioengineering Division
  • ISBN: 978-0-7918-4321-5
  • Copyright © 2008 by ASME

abstract

The stretch response of myofibroblast cells cultured in a three-dimensional environment was simultaneously measured and observed using a tissue stretching apparatus mounted to a confocal microscope. Optical measurements were used to assess mechanical estimates of cell response obtained through combined mechanical testing and biochemical inhibition. Results show that activated myofibroblasts provide an effective resistance on the order of 100s of kPa. In specific mechanical environments, stretched myofibroblasts release the ECM.

Copyright © 2008 by ASME

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