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Mechano-Regulation of Stem Cell Differentiation During Bending Stimulation of a Healing Bone Defect

[+] Author Affiliations
Lauren N. M. Hayward, Elise F. Morgan

Boston University, Boston, MA

Paper No. SBC2008-192981, pp. 551-552; 2 pages
doi:10.1115/SBC2008-192981
From:
  • ASME 2008 Summer Bioengineering Conference
  • ASME 2008 Summer Bioengineering Conference, Parts A and B
  • Marco Island, Florida, USA, June 25–29, 2008
  • Conference Sponsors: Bioengineering Division
  • ISBN: 978-0-7918-4321-5
  • Copyright © 2008 by ASME

abstract

Mechanical stimulation of a bone fracture can alter the course of tissue differentiation [1]. Quantitative characterization of this mechano-regulatory effect has great therapeutic potential. For example, mechano-regulation theories are already being applied to tailor scaffold designs in tissue engineering applications [2]. Approaches such as these may lead to improved treatment of bone and joint degeneration as well as treatment of orthopedic injuries.

Copyright © 2008 by ASME
Topics: Bone , Stem cells

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