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Metabolite Transport Inside Channeled Porous Scaffolds for Haematopoietic Stem Cell Culture: A Computational Study

[+] Author Affiliations
Marco Cantini, Gianfranco B. Fiore, Alberto Redaelli, Monica Soncini

Politecnico di Milano, Milan, Italy

Paper No. SBC2008-192852, pp. 481-482; 2 pages
doi:10.1115/SBC2008-192852
From:
  • ASME 2008 Summer Bioengineering Conference
  • ASME 2008 Summer Bioengineering Conference, Parts A and B
  • Marco Island, Florida, USA, June 25–29, 2008
  • Conference Sponsors: Bioengineering Division
  • ISBN: 978-0-7918-4321-5
  • Copyright © 2008 by ASME

abstract

Porous polymeric materials play a key role in regenerative medicine, serving as three-dimensional scaffolds for cell culture. Hence, the definition of their micro-architecture should be regarded as a pivotal design issue, that has to be wittingly addressed while engineering a cell culture system. Computational fluid dynamics techniques (CFD) appear to be very valuable in this respect, since they have been appreciably applied in recent literature as a means to analyze fluid dynamics and mass transport inside scaffold or bioreactor models [1]; moreover, leading researchers in tissue engineering have acknowledged the role of numerical methodology in the issue of defining optimal flow conditions for three-dimensional dynamic culture systems.

Copyright © 2008 by ASME

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