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Effects of Mechanical Strain on Syndecan-4, Focal Adhesion Complexes, and Site-Specific FAK Phosphorylation

[+] Author Affiliations
Chao-Min Cheng, Robert L. Steward, Jr., Philip R. LeDuc

Carnegie Mellon University, Pittsburgh, PA

Danny L. Wang

Academia Sinica, Taipei, Taiwan

Paper No. SBC2008-192360, pp. 265-266; 2 pages
doi:10.1115/SBC2008-192360
From:
  • ASME 2008 Summer Bioengineering Conference
  • ASME 2008 Summer Bioengineering Conference, Parts A and B
  • Marco Island, Florida, USA, June 25–29, 2008
  • Conference Sponsors: Bioengineering Division
  • ISBN: 978-0-7918-4321-5
  • Copyright © 2008 by ASME

abstract

Cellular mechanics involves the ability of cells to sense and respond to external forces. The type of deformations that cells undergo such as stretching, compression or shearing depends on physiological conditions such as how muscle deforms during movement. Using a custom fabricated stretching device, we focused on investigating how statically applied mechanical stretch affects syndecan-4, focal adhesion complexes and phosphorylated focal adhesion kinase (p-FAK). These results have potential implications in a variety of fields including biophysics, mechanotransduction, and cellular structure.

Copyright © 2008 by ASME
Topics: Adhesion

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