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Electrospinning of Photopolymerizable Poly(β-Amino Ester) Networks for Fibrous Tissue Engineering

[+] Author Affiliations
Andrea R. Tan, Jamie L. Ifkovits, Brendon M. Baker, Robert L. Mauck, Jason A. Burdick

University of Pennsylvania, Philadelphia, PA

Paper No. SBC2007-176206, pp. 997-998; 2 pages
doi:10.1115/SBC2007-176206
From:
  • ASME 2007 Summer Bioengineering Conference
  • ASME 2007 Summer Bioengineering Conference
  • Keystone, Colorado, USA, June 20–24, 2007
  • Conference Sponsors: Bioengineering Division
  • ISBN: 0-7918-4798-5
  • Copyright © 2007 by ASME

abstract

Fiber-reinforced tissues of the musculoskeletal system, including tendon, ligament, intervertebral disc, and the knee meniscus function to transmit the high mechanical forces that arise with locomotion. As these tissues operate under demanding mechanical regimes, their structure and composition are optimized to enable these activities and to resist damage with repeated use. Hallmarks of these dense fibrous tissues include a high collagen content organized along a prevailing fiber direction that is generally coincident with the principal loading direction, as well as a lack of vascularity after skeletal maturation. While these characteristics enable function, they also predispose these tissues to a poor healing response subsequent to injury.

Copyright © 2007 by ASME

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