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Mechanical Stimulation Increases Collagen Type I and Collagen Type III Gene Expression of Stem Cell: Collagen Sponge Constructs for Patellar Tendon Repair

[+] Author Affiliations
Natalia Juncosa-Melvin, Robert W. Holdcraft, Victor S. Nirmalanandhan, David L. Butler

University of Cincinnati, Cincinnati, OH

Karl S. Matlin

University of Chicago, Chicago, IL

Paper No. SBC2007-175807, pp. 981-982; 2 pages
doi:10.1115/SBC2007-175807
From:
  • ASME 2007 Summer Bioengineering Conference
  • ASME 2007 Summer Bioengineering Conference
  • Keystone, Colorado, USA, June 20–24, 2007
  • Conference Sponsors: Bioengineering Division
  • ISBN: 0-7918-4798-5
  • Copyright © 2007 by ASME

abstract

Tendons (rotator cuff, Achilles and patellar tendons) are among the most commonly injured soft tissues [1]. Many repairs/reconstructions have been attempted using sutures, resorbable biomaterials, autografts, and allografts, but with varying success. A tissue engineered repair using mesenchymal stem cells (MSCs) is attractive [2–4] but often lacks initial stiffness and strength [5].

Copyright © 2007 by ASME

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