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Mechanical and Biochemical Comparison of Cell-Derived Matrix, Collagen Gels, and Fibrin Gels for Tissue Engineering Applications

[+] Author Affiliations
Jan-Eric W. Ahlfors

Total ReCord, Inc., Worcester, MA

Kristen L. Billiar

Worcester Polytechnic Institute, Worcester, MA

Paper No. SBC2007-175401, pp. 979-980; 2 pages
  • ASME 2007 Summer Bioengineering Conference
  • ASME 2007 Summer Bioengineering Conference
  • Keystone, Colorado, USA, June 20–24, 2007
  • Conference Sponsors: Bioengineering Division
  • ISBN: 0-7918-4798-5
  • Copyright © 2007 by ASME


Cell-seeded collagen and fibrin gels have been used extensively as in vitro wound healing models and for studying tissue remodeling. The have also been utilized as replacements for lost or damaged connective tissue [1]. The major drawback of these gel-based living tissue equivalents (LTEs) for tissue engineering applications is that they are not completely synthesized and arranged by the cells themselves, thus they are weak relative to native connective tissue.

Copyright © 2007 by ASME



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