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Two Methods of Determining [3H]Dexamethasone Distribution in Rat Subcutaneous Tissue

[+] Author Affiliations
Paul Dungel, Yvonne Moussy, Lawrence Hersh

University of South Florida, Tampa, FL

Paper No. SBC2007-172803, pp. 95-96; 2 pages
doi:10.1115/SBC2007-172803
From:
  • ASME 2007 Summer Bioengineering Conference
  • ASME 2007 Summer Bioengineering Conference
  • Keystone, Colorado, USA, June 20–24, 2007
  • Conference Sponsors: Bioengineering Division
  • ISBN: 0-7918-4798-5
  • Copyright © 2007 by ASME

abstract

Several recent reports suggest that controlled local release of dexamethasone may be useful for preventing inflammation around an implantable glucose sensor [1,2]. This decrease in inflammation is expected to increase glucose sensor function and lifetime. Local delivery of dexamethasone would permit high interstitial drug concentrations at the site of glucose sensor implantation without producing high systemic drug levels. Although dexamethasone is a commonly used anti-inflammatory agent, its local concentration, diffusion coefficient and rate of elimination have not been reported following subcutaneous release. The ability of dexamethasone to penetrate subcutaneous tissue can be measured and quantified by comparison to mathematical models [3]. This method allows a reliable estimate of the drug concentration in the tissue near the implanted glucose sensor.

Copyright © 2007 by ASME

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