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Elasticity of Cartilage Measured by Large Strain, Non-Hertzian AFM Nanoindentation

[+] Author Affiliations
David C. Lin, Emilios K. Dimitriadis, Ferenc Horkay

National Institutes of Health, Bethesda, MD

Paper No. SBC2007-176618, pp. 945-946; 2 pages
doi:10.1115/SBC2007-176618
From:
  • ASME 2007 Summer Bioengineering Conference
  • ASME 2007 Summer Bioengineering Conference
  • Keystone, Colorado, USA, June 20–24, 2007
  • Conference Sponsors: Bioengineering Division
  • ISBN: 0-7918-4798-5

abstract

The raster scanning and nanoindentation capabilities of the AFM are exploited in force spectroscopy, a valuable quantitative technique for mapping the elastic properties of materials down to nanometer resolution. When the probe is of well-defined geometry and the indentation behavior can be represented by established contact mechanics models, the force maps can be transformed to elastic modulus maps to facilitate comparison. This is especially important in biological specimens, where sample-to-sample variability is usually high.

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