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Viscoelastic Properties of Injured and Uninjured Rat Brain Tissue

[+] Author Affiliations
Mehdi Shafieian, Kurosh Darvish

Temple University, Philadelphia, PA

Paper No. SBC2007-176055, pp. 889-890; 2 pages
  • ASME 2007 Summer Bioengineering Conference
  • ASME 2007 Summer Bioengineering Conference
  • Keystone, Colorado, USA, June 20–24, 2007
  • Conference Sponsors: Bioengineering Division
  • ISBN: 0-7918-4798-5
  • Copyright © 2007 by ASME


In this study, changes in the viscoelastic material properties of brain tissue due to traumatic diffuse axonal injury (DAI) were investigated. The impact acceleration model was used to generate DAI in rat brain stem. The viscoelastic material properties of brain tissue along the corticospinal (CSpT) tract in the brain stem were characterized using an indentation technique and a quasilinear theory. The results show significant reduction in the elastic response of brain tissue due to injury. In regions with significantly more DAI, larger changes in the elastic shear modulus and relaxation function were observed. These findings can improve the injury predictability of computational models of brain injury.

Copyright © 2007 by ASME



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