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Investigation of Cartilage Biomechanical Properties: Dependence on Strain, Direction, and Biochemical Composition

[+] Author Affiliations
Gregory C. Thomas, Timothy P. Ficklin, James C. Barthel, Andrew Davol, Stephen M. Klisch

California Polytechnic State University, San Luis Obispo, CA

Anna Asanbaeva, Albert C. Chen, Robert L. Sah

University of California, San Diego, La Jolla, CA

Eugene J.-M. A. Thonar, Koichi Masuda

Rush Medical Center, Chicago, IL

Paper No. SBC2007-175965, pp. 877-878; 2 pages
doi:10.1115/SBC2007-175965
From:
  • ASME 2007 Summer Bioengineering Conference
  • ASME 2007 Summer Bioengineering Conference
  • Keystone, Colorado, USA, June 20–24, 2007
  • Conference Sponsors: Bioengineering Division
  • ISBN: 0-7918-4798-5
  • Copyright © 2007 by ASME

abstract

Articular cartilage (AC) serves as the major load bearing material within synovial joints and provides a low friction and wear resistant interface. As an avascular tissue, AC lacks the ability to repair structural damage or degeneration. Thus, the need for replacement tissue was a motivating factor in the development of cartilage tissue engineering. Recently, a finite element model (FEM) of cartilage growth [1] has been developed to simulate various growth conditions such as in vitro (outside the body) tissue growth experiments. In order to validate growth laws used in the FEM, empirical measurements of AC properties (mechanical and biochemical) before and after in vitro growth are needed. The goal of this study is to design protocols to comprehensively quantify the biomechanical structure-function relations of AC.

Copyright © 2007 by ASME

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