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Micromotions at the Bone Implant Interface Up-Regulate Osteoblasts-Mediated Activation of Osteoclasts in Ex Vivo Human Samples

[+] Author Affiliations
Vincent A. Stadelmann, Dominique P. Pioletti

Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland

Paper No. SBC2007-175743, pp. 865-866; 2 pages
  • ASME 2007 Summer Bioengineering Conference
  • ASME 2007 Summer Bioengineering Conference
  • Keystone, Colorado, USA, June 20–24, 2007
  • Conference Sponsors: Bioengineering Division
  • ISBN: 0-7918-4798-5
  • Copyright © 2007 by ASME


A radiolucent zone at the interface of bone and implants in total joint prosthesis is frequently observed in uncemented and cemented implants. This radiolucent zone, representing a fibrous tissue, is the result of the progressive deterioration of the bone surrounding implants. Fibrous tissues affect the implant fixation, increasing then the risk of aseptic loosening. Today, aseptic loosening is the most common cause of arthroplasties revisions.

Copyright © 2007 by ASME
Topics: Bone , Osteoblasts



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