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A Cartilage Growth Mixture Model With Collagen Remodeling: Validation Protocols

[+] Author Affiliations
Stephen M. Klisch, Sevan R. Oungoulian, Andrew Davol

California Polytechnic State University, San Luis Obispo, CA

Anna Asanbaeva, Robert L. Sah

University of California, San Diego, La Jolla, CA

Eugene J.-M. A. Thonar, Koichi Masuda

Rush Medical Center, Chicago, IL

Paper No. SBC2007-175548, pp. 861-862; 2 pages
  • ASME 2007 Summer Bioengineering Conference
  • ASME 2007 Summer Bioengineering Conference
  • Keystone, Colorado, USA, June 20–24, 2007
  • Conference Sponsors: Bioengineering Division
  • ISBN: 0-7918-4798-5
  • Copyright © 2007 by ASME


The attainment of specific design goals related to tissue structure and function is likely critical to the development of a consistently successful strategy for articular cartilage (AC) repair. The long-term goal of this research is to develop a cartilage growth mixture (CGM) model that may be used with experimental approaches to improve AC repair strategies. The CGM employs a “stress balance” hypothesis: at equilibrium, the crosslinked collagen (COL) network restrains the proteoglycan (PG) swelling pressure generated by fixed charge density. The specific objectives are to: 1) refine a previous CGM model [1] to include COL remodeling; 2) develop analytical protocols for model validation that are based on experimental data from select in vitro growth protocols; and 3) test CGM model hypotheses.

Copyright © 2007 by ASME
Topics: Cartilage



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