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Mechanical Loading Uniquely Up-Regulates MMP-13 in Rat Supraspinatus Tendon But Not Achilles Tendon

[+] Author Affiliations
Gail M. Thornton, Xinxin Shao, May Chung, Paul Sciore, Richard S. Boorman, David A. Hart, Ian K. Y. Lo

University of Calgary, Calgary, AB, Canada

Paper No. SBC2007-173778, pp. 839-840; 2 pages
  • ASME 2007 Summer Bioengineering Conference
  • ASME 2007 Summer Bioengineering Conference
  • Keystone, Colorado, USA, June 20–24, 2007
  • Conference Sponsors: Bioengineering Division
  • ISBN: 0-7918-4798-5
  • Copyright © 2007 by ASME


Tendon injuries and chronic pain, known as tendinopathy, are extremely common in supraspinatus and Achilles tendons. Despite their prevalence, the pathogenesis of these conditions is poorly understood. One of most common cited factors for injuries to the rotator cuff tendons is “impingement”, namely, mechanical compression of the supraspinatus tendon by the overlying coracoacromial arch [1]. To date, few studies have investigated the molecular processes underlying this condition.

Copyright © 2007 by ASME
Topics: Tendons



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