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Anisotropic Strain Effects on Vascular Smooth Muscle Cell Physiology

[+] Author Affiliations
Vadim Tsvankin, Dmitry Belchenko, Devon Scott

University of Colorado, Boulder, CO

Wei Tan

University of Colorado, Boulder, COUniversity of Colorado Health Sciences Center, Denver, CO

Paper No. SBC2007-176284, pp. 805-806; 2 pages
doi:10.1115/SBC2007-176284
From:
  • ASME 2007 Summer Bioengineering Conference
  • ASME 2007 Summer Bioengineering Conference
  • Keystone, Colorado, USA, June 20–24, 2007
  • Conference Sponsors: Bioengineering Division
  • ISBN: 0-7918-4798-5
  • Copyright © 2007 by ASME

abstract

Biological development is a complex and highly-regulated process, a significant part of which is controlled by mechanostimulus, or the strain imparted on a cell by its environment. Mechanostimulus is important for stem cell differentiation, from cytoskeletal assembly to cell-cell and cell-matrix adhesion [1]. The mechanics of cells and tissues play a critical role in organisms, under both physiological and pathological conditions; abnormal mechanotransduction — the mechanism by which cells sense and respond to strain — has been implicated in a wide range of clinical pathologies [2,3].

Copyright © 2007 by ASME
Topics: Muscle , Physiology

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