Full Content is available to subscribers

Subscribe/Learn More  >

Mesenchymal Progenitor Cells Differentially Respond to Mechanical Stimulation: Morphology, Proliferation, Gene and Protein Expression

[+] Author Affiliations
Timothy M. Maul, Douglas W. Chew, Alejandro Nieponice, David A. Vorp

University of Pittsburgh, Pittsburgh, PA

Paper No. SBC2007-175994, pp. 797-798; 2 pages
  • ASME 2007 Summer Bioengineering Conference
  • ASME 2007 Summer Bioengineering Conference
  • Keystone, Colorado, USA, June 20–24, 2007
  • Conference Sponsors: Bioengineering Division
  • ISBN: 0-7918-4798-5
  • Copyright © 2007 by ASME


Mechanical stimulation has been shown to regulate gene and protein expression in many cell types, including stem cells. Cyclic strain has been previously shown by our laboratory and others [1, 2] to regulate smooth muscle gene and protein expression in mesenchymal progenitor cells (MPCs). From these and other results [3], we hypothesize that the differentiated phenotype of MPCs may be controlled by the appropriate type, magnitude, and frequency of mechanical stimulation. We describe here the differential response of MPCs to three mechanical stimuli — cyclic strain, cyclic hydrostatic pressure, and laminar shear stress — over a range of magnitudes and frequencies that are consistent with the cardiovascular system.

Copyright © 2007 by ASME
Topics: Proteins , Stem cells



Interactive Graphics


Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging and repositioning the boxes below.

Related eBook Content
Topic Collections

Sorry! You do not have access to this content. For assistance or to subscribe, please contact us:

  • TELEPHONE: 1-800-843-2763 (Toll-free in the USA)
  • EMAIL: asmedigitalcollection@asme.org
Sign In