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Anatomically Correct Right Coronary Artery Model

[+] Author Affiliations
Helen Lentzakis, Leonie Rouleau

McGill University, Montreal, QC, Canada

Monica Farcas

University of Toronto, Toronto, ON, Canada

Richard L. Leask

McGill University, Montreal, QC, CanadaMontreal Heart Institute, Montreal, QC, Canada

Paper No. SBC2007-172212, pp. 791-792; 2 pages
doi:10.1115/SBC2007-172212
From:
  • ASME 2007 Summer Bioengineering Conference
  • ASME 2007 Summer Bioengineering Conference
  • Keystone, Colorado, USA, June 20–24, 2007
  • Conference Sponsors: Bioengineering Division
  • ISBN: 0-7918-4798-5
  • Copyright © 2007 by ASME

abstract

Upon clinical analysis, regions such as curvatures and bifurcations have been characterized as high prone regions where atherosclerotic plaques were more likely to occur. Biological studies have linked this phenomenon to the localized response of the endothelial cells to mechanical blood flow forces such as fluid shear stress. Present common in vitro flow cell culture models such as parallel-plate flow chambers and cone and plate viscometers used to study endothelial cell response depict a simplified geometry and thus, unrealistic in vivo conditions. The aim of this project was to develop a more realistic in vitro cell culture model by using an anatomically correct right coronary artery model and a more physiologic flow environment for dynamic endothelial cell culture experiments.

Copyright © 2007 by ASME

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