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Stent Induced Smooth Muscle Cell Proliferation: An In Vitro System for Rapid Evaluation

[+] Author Affiliations
Joel L. Berry, Saami K. Yazdani

Virginia Tech-Wake Forest University School of Biomedical Engineering and Sciences, Winston-Salem, NC

Paper No. SBC2007-176798, pp. 767-768; 2 pages
  • ASME 2007 Summer Bioengineering Conference
  • ASME 2007 Summer Bioengineering Conference
  • Keystone, Colorado, USA, June 20–24, 2007
  • Conference Sponsors: Bioengineering Division
  • ISBN: 0-7918-4798-5
  • Copyright © 2007 by ASME


The clinical efficacy of vascular stents is evaluated through long and expensive trials. Pre-clinical studies, where stents are tested in animal models, further contribute to the expense of bringing new devices to market. The purpose of pre-clinical studies is to assess stent induced thrombus formation, inflammatory response, neointimal hyperplasia, and late thromobosis. Whether the trial is pre-clinical or clinical, the biologic responses to stents are, in large part, due to the surface and structural characteristics of the stent being tested.

Copyright © 2007 by ASME
Topics: Muscle , stents



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