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A Genetic-Algorithm-Based Design Approach to Minimize Abnormal Hemodynamics Parameters at the End-to-Side Distal Anastomoses of Synthetic Bypass Grafts

[+] Author Affiliations
Zaher El Zahab, Eduardo A. Divo, Alain J. Kassab

University of Central Florida, Orlando, FL

Paper No. SBC2007-176718, pp. 761-762; 2 pages
doi:10.1115/SBC2007-176718
From:
  • ASME 2007 Summer Bioengineering Conference
  • ASME 2007 Summer Bioengineering Conference
  • Keystone, Colorado, USA, June 20–24, 2007
  • Conference Sponsors: Bioengineering Division
  • ISBN: 0-7918-4798-5
  • Copyright © 2007 by ASME

abstract

Medical records on post-operative performances of synthetic bypass grafting show poor results due to the re-stenosis occurring at the end-to-side distal (ETSD) anastomoses of the grafts. The re-stenosis is mainly caused by intimal hyperplasia (IH) [1]. A major factor behind the anastomotic IH development is the non-physiological flow patterns, such as separation and re-attachment, resulting from the bifurcating nature of the anastomotic geometry [2]. The spatial wall shear stress gradient (SWSSG) has been experimentally proven to cause proliferation and migration of the endothelial cells [3], resulting in an endothelial dysfunction that potentially leads to the initiation of IH.

Copyright © 2007 by ASME

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