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BioMEMS Platform for Electromechanical Stimulation of Cell Culture

[+] Author Affiliations
Jennifer Blundo, Gretchen Chua, Oscar Abilez, Yong-Lae Park, Ali Rastegar, Feng Cao, Chris Zarins, Joe Wu, Beth Pruitt

Stanford University, Stanford, CA

Paper No. SBC2007-176716, pp. 63-64; 2 pages
  • ASME 2007 Summer Bioengineering Conference
  • ASME 2007 Summer Bioengineering Conference
  • Keystone, Colorado, USA, June 20–24, 2007
  • Conference Sponsors: Bioengineering Division
  • ISBN: 0-7918-4798-5
  • Copyright © 2007 by ASME


A BioMEMS platform was designed and fabricated to enable electromechanical stimulation of cell cultures. The device consists of a stretchable microelectrode array embedded in a biocompatible elastomeric polymer, which is deformed by vacuum over a glass baseplate. The entire device is optically transparent and ∼1mm thick. Four cell culture wells apply electrical and/or mechanical stimulation in the range of 1–10 V/cm and 0–10% equibiaxial strain. Studies of electromechanical stimulation of cardiac myocyte precursors on this platform are proposed to elucidate mechanisms of differentiation.

Copyright © 2007 by ASME



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