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MRI Measurement of Surface Strain Due to Growth in the Developing Ferret Brain

[+] Author Affiliations
Andrew K. Knutsen, Larry A. Taber, Philip V. Bayly

Washington University, St. Louis, MO

Christopher D. Kroenke

Oregon Health & Science University, Portland, OR

Jeffrey J. Neil

Washington University School of Medicine, St. Louis, MO

Paper No. SBC2007-176010, pp. 551-552; 2 pages
  • ASME 2007 Summer Bioengineering Conference
  • ASME 2007 Summer Bioengineering Conference
  • Keystone, Colorado, USA, June 20–24, 2007
  • Conference Sponsors: Bioengineering Division
  • ISBN: 0-7918-4798-5
  • Copyright © 2007 by ASME


The human cerebral cortex undergoes folding from the 5th fetal month into the first post-natal year. Disturbances of folding have serious and lasting consequences, but the mechanism is not well understood. Van Essen [1] has hypothesized that axonal tension between strongly interconnected regions draws them together and induces outward folds. However, no direct measurements have confirmed this theory. Experimental data are needed, beginning with a quantitative description of the kinematics of cortical growth during folding.

Copyright © 2007 by ASME



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